ARHGEF2

Across TCGA patient cohorts, ARHGEF2 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,417 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible ARHGEF2-associated proteins across cancer lineages are ARHGEF2_S932, ARHGEF2_S174, and ARHGEF2_S711. Each is linked with ARHGEF2 in more than 7 cancer types. Because this analysis shows association rather than direction, both ARHGEF2-to-partner and partner-to-ARHGEF2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARHGEF2 versus ARHGEF2_S932 in BRCA, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF2→partner) and Y-score (partner→ARHGEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGEF2_S932 →	+0.669	+0.677	<.001	<.001	3	8
PDAC	ARHGEF2_S174 →	+0.883	+0.422	<.001	<.001	3	6
LUAD	ARHGEF2_S711 →	+0.718	+0.963	<.001	<.001	3	6
HNSC	RPRD2 →	+0.298	+0.537	.001	.002	3	5
GBM	PARP1 →	+0.464	+0.461	<.001	<.001	3	5
GBM	PRPF4 →	+0.267	+0.411	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,417 associations by consensus.

ARHGEF2 vs ARHGEF2_S932 — BRCA

Explore this scatter interactively →