ARHGEF2

Across TCGA patient cohorts, ARHGEF2 protein abundance is significantly associated with the RNA expression of many other genes, with 17,141 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ARHGEF2-associated genes across cancer lineages are DESI2, POGK, and UCK2. Each is linked with ARHGEF2 in more than 6 cancer types. Because this analysis shows association rather than direction, both ARHGEF2-to-partner and partner-to-ARHGEF2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARHGEF2 versus DESI2 in BRCA, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF2→partner) and Y-score (partner→ARHGEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DESI2 →	+0.650	+0.443	<.001	<.001	3	7
UCEC	POGK →	+0.503	+0.363	<.001	<.001	3	6
UCEC	UCK2 →	+0.978	+0.313	<.001	<.001	3	6
GBM	EXO1 →	+1.014	+0.330	.001	.001	3	6
OV	IQGAP3 →	+1.042	+0.264	.003	.007	3	6
UCEC	TIPRL →	+0.953	+0.424	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,141 associations by consensus.

ARHGEF2 vs DESI2 — BRCA

Explore this scatter interactively →