ARHGEF2

Across TCGA patient cohorts, ARHGEF2 mutation is significantly associated with the RNA expression of many other genes, with 2,787 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF2-associated genes across cancer lineages are MRPL44, NCAPH, and JPT1. Each is linked with ARHGEF2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGEF2-to-partner and partner-to-ARHGEF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL44 grouped by ARHGEF2-low versus ARHGEF2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF2→partner) and Y-score (partner→ARHGEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MRPL44 →	+0.443	+2.642	.009	.005	3	4
SKCM	NCAPH →	+0.578	+3.604	.005	.001	3	4
SKCM	JPT1 →	+0.464	+2.728	.004	.003	3	3
SKCM	ARHGAP11A →	+0.677	+2.132	.003	.003	3	3
UCEC	EME1 →	+0.551	+1.868	<.001	<.001	3	3
UCEC	MED8 →	+0.242	+1.900	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,787 associations by consensus.

MRPL44 by ARHGEF2 expression — SKCM

Explore this box plot interactively →