ARHGEF2

Across TCGA patient cohorts, ARHGEF2 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF2-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and Bak. Each is linked with ARHGEF2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGEF2-to-partner and partner-to-ARHGEF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ARHGEF2-low versus ARHGEF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF2→partner) and Y-score (partner→ARHGEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.467	+1.697	.012	.012	3	4
SKCM	PCNA →	+0.307	+2.700	<.001	.006	3	3
UCEC	Bak →	+0.231	+1.584	.003	.005	3	3
SKCM	Chk1 →	+0.195	+3.182	.022	.009	3	3
UCEC	Ku80 →	+0.245	+1.935	<.001	.002	3	2
UCEC	mTOR_pS2448 →	-0.194	-2.649	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Caspase-7-cleavedD198 by ARHGEF2 expression — UCEC

Explore this box plot interactively →