ARHGEF2

Across TCGA cell cohorts, ARHGEF2 mutation is significantly associated with the RNA expression of many other genes, with 707 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGEF2-associated genes across cancer lineages are CUEDC2, TTI2, and GRSF1. Each is linked with ARHGEF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF2-to-partner and partner-to-ARHGEF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CUEDC2 grouped by ARHGEF2-low versus ARHGEF2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF2→partner) and Y-score (partner→ARHGEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CUEDC2 →	+0.595	+3.234	.001	.004	3	2
LARGE_INTESTINE	TTI2 →	+0.626	+2.502	.001	.005	3	2
LARGE_INTESTINE	GRSF1 →	+0.567	+2.502	<.001	.005	3	2
LARGE_INTESTINE	ACOT12 →	+0.020	+1.894	.008	.009	3	2
BLOOD_Leukemia	TIGD3 →	+0.538	+3.199	<.001	.007	3	2
LARGE_INTESTINE	FKBPL →	+0.512	+3.459	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 707 associations by consensus.

CUEDC2 by ARHGEF2 expression — LARGE_INTESTINE

Explore this box plot interactively →