ARHGEF19

Across TCGA patient cohorts, ARHGEF19 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF19-associated genes across cancer lineages are ASNS, EGFR_pY1068, and FoxM1. Each is linked with ARHGEF19 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGEF19-to-partner and partner-to-ARHGEF19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ARHGEF19-low versus ARHGEF19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF19→partner) and Y-score (partner→ARHGEF19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.342	+2.000	.016	.030	3	3
UCEC	EGFR_pY1068 →	-0.317	-2.502	.001	.002	3	2
UCEC	FoxM1 →	+0.238	+2.000	.019	.010	3	2
UCEC	Shc_pY317 →	-0.181	-2.115	.002	.017	3	2
UCEC	14-3-3_beta →	-0.125	-2.489	.001	.002	3	1
UCEC	EGFR →	-0.165	-3.321	.008	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ASNS by ARHGEF19 expression — UCEC

Explore this box plot interactively →