ARHGEF19

Across TCGA cell cohorts, ARHGEF19 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,216 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARHGEF19-associated GO terms across cancer lineages are Regulation of attachment of mitotic spindle microtubules to kinetochore, Spliceosomal tri-snRNP complex assembly, and Regulation of myoblast fusion. Each is linked with ARHGEF19 in more than 9 cancer types. Because this analysis shows association rather than direction, both ARHGEF19-to-partner and partner-to-ARHGEF19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of attachment of mitotic spindle microtubules to kinetochore grouped by ARHGEF19-low versus ARHGEF19-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF19→partner) and Y-score (partner→ARHGEF19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.116	+1.913	.002	<.001	3	10
LUNG_NSCLC_LUAD	Spliceosomal tri-snRNP complex assembly →	+0.060	+1.057	.002	<.001	3	10
OVARY	Regulation of myoblast fusion →	+0.075	+1.066	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of RNA splicing →	+0.087	+0.987	<.001	.001	3	9
OVARY	Negative regulation of syncytium formation by plasma membrane fusion →	+0.091	+1.042	<.001	<.001	3	9
OESOPHAGUS	Wnt signaling pathway, planar cell polarity pathway →	+0.133	+1.162	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,216 associations by consensus.

Regulation of attachment of mitotic spindle microtubules to kinetochore by ARHGEF19 expression — LUNG_SCLC

Explore this box plot interactively →