ARHGEF19

Across TCGA cell cohorts, ARHGEF19 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGEF19-associated genes across cancer lineages are GHRHR, C20orf85, and IL22. Each is linked with ARHGEF19 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF19-to-partner and partner-to-ARHGEF19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRHR grouped by ARHGEF19-low versus ARHGEF19-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF19→partner) and Y-score (partner→ARHGEF19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GHRHR →	+0.408	+3.705	<.001	.007	3	1
BLOOD_Leukemia	C20orf85 →	+0.029	+4.384	<.001	.006	3	1
BLOOD_Leukemia	IL22 →	+0.030	+4.984	<.001	.002	3	1
BLOOD_Leukemia	FAM71B →	+0.019	+4.060	<.001	.003	3	1
BLOOD_Leukemia	PROP1 →	+0.033	+3.874	<.001	.005	3	1
BLOOD_Leukemia	GFRAL →	+0.020	+4.984	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

GHRHR by ARHGEF19 expression — BLOOD_Leukemia

Explore this box plot interactively →