ARHGEF18

Across TCGA patient cohorts, ARHGEF18 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,153 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible ARHGEF18-associated GO terms across cancer lineages are Viral translational termination-reinitiation, Regulation of autophagosome maturation, and Positive regulation of protein acetylation. Each is linked with ARHGEF18 in more than 29 cancer types. Because this analysis shows association rather than direction, both ARHGEF18-to-partner and partner-to-ARHGEF18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral translational termination-reinitiation grouped by ARHGEF18-low versus ARHGEF18-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF18→partner) and Y-score (partner→ARHGEF18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Viral translational termination-reinitiation →	+0.120	+0.947	<.001	<.001	3	30
SCLC	Regulation of autophagosome maturation →	+0.099	+0.509	<.001	<.001	3	29
SCLC	Positive regulation of protein acetylation →	+0.102	+0.597	.001	.003	3	29
SCLC	Epigenetic regulation of gene expression →	+0.081	+0.650	<.001	<.001	3	29
SCLC	Negative regulation of gene expression, epigenetic →	+0.108	+0.588	<.001	<.001	3	29
THYM	Protein autophosphorylation →	+0.038	+0.788	<.001	.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,153 associations by consensus.

Viral translational termination-reinitiation by ARHGEF18 expression — SCLC

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