ARHGEF18

Across TCGA patient cohorts, ARHGEF18 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF18-associated genes across cancer lineages are ERK2, Caspase-7-cleavedD198, and Caspase-8. Each is linked with ARHGEF18 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGEF18-to-partner and partner-to-ARHGEF18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ARHGEF18-low versus ARHGEF18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF18→partner) and Y-score (partner→ARHGEF18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.156	+1.415	.009	.010	3	4
COAD	Caspase-7-cleavedD198 →	+1.576	+2.824	<.001	.034	3	4
UCEC	Caspase-8 →	-0.179	-1.652	.022	.005	3	2
UCEC	eEF2 →	+0.246	+2.584	.026	.010	3	2
COAD	MSH6 →	-0.613	-3.000	.001	.034	3	2
UCEC	PCNA →	+0.148	+1.440	.027	.022	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ERK2 by ARHGEF18 expression — UCEC

Explore this box plot interactively →