ARHGEF18

Across TCGA cell cohorts, ARHGEF18 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,511 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ARHGEF18-associated GO terms across cancer lineages are Endosomal transport, Positive regulation of anaphase-promoting complex-dependent catabolic process, and Retrograde transport, endosome to Golgi. Each is linked with ARHGEF18 in more than 15 cancer types. Because this analysis shows association rather than direction, both ARHGEF18-to-partner and partner-to-ARHGEF18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endosomal transport grouped by ARHGEF18-low versus ARHGEF18-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF18→partner) and Y-score (partner→ARHGEF18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Endosomal transport →	+0.087	+1.384	<.001	<.001	3	16
SOFT_TISSUE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.148	+1.017	<.001	<.001	3	16
STOMACH	Retrograde transport, endosome to Golgi →	+0.089	+1.104	.002	.007	3	15
STOMACH	Endocytic recycling →	+0.083	+1.061	<.001	<.001	3	14
STOMACH	Vesicle-mediated transport to the plasma membrane →	+0.098	+1.234	<.001	<.001	3	14
BREAST	Regulation of nucleocytoplasmic transport →	+0.078	+0.709	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,511 associations by consensus.

Endosomal transport by ARHGEF18 expression — STOMACH

Explore this box plot interactively →