ARHGEF17

Across TCGA cell cohorts, ARHGEF17 mutation is significantly associated with the RNA expression of many other genes, with 771 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGEF17-associated genes across cancer lineages are OR6V1, OR13C5, and SIGLEC5. Each is linked with ARHGEF17 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGEF17-to-partner and partner-to-ARHGEF17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6V1 grouped by ARHGEF17-low versus ARHGEF17-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF17→partner) and Y-score (partner→ARHGEF17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR6V1 →	+0.011	+2.662	<.001	.007	3	3
BREAST	OR13C5 →	+0.023	+4.312	<.001	.001	3	2
OESOPHAGUS	SIGLEC5 →	+0.006	+4.906	<.001	.006	3	2
OESOPHAGUS	AADACL3 →	+0.410	+4.906	<.001	.006	3	2
LARGE_INTESTINE	HSCB →	+0.485	+2.130	.001	<.001	3	2
LARGE_INTESTINE	ZNF330 →	+0.396	+2.526	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 771 associations by consensus.

OR6V1 by ARHGEF17 expression — STOMACH

Explore this box plot interactively →