ARHGEF16

Across TCGA patient cohorts, ARHGEF16 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,061 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible ARHGEF16-associated proteins across cancer lineages are ARHGEF16_S230, ARHGEF16_S107, and ARHGEF16_S174. Each is linked with ARHGEF16 in more than 8 cancer types. Because this analysis shows association rather than direction, both ARHGEF16-to-partner and partner-to-ARHGEF16 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARHGEF16 versus ARHGEF16_S230 in BRCA, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF16→partner) and Y-score (partner→ARHGEF16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGEF16_S230 →	+1.074	+0.862	<.001	<.001	3	9
PDAC	ARHGEF16_S107 →	+1.490	+0.846	<.001	<.001	3	6
LSCC	ARHGEF16_S174 →	+0.878	+0.918	<.001	<.001	3	6
BRCA	GALE →	+0.569	+0.888	<.001	.001	3	6
CCRCC	PPP1R18 →	-0.360	-0.959	<.001	.001	3	5
LUAD	PEX14 →	+0.413	+0.585	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,061 associations by consensus.

ARHGEF16 vs ARHGEF16_S230 — BRCA

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