ARHGEF16

Across TCGA patient cohorts, ARHGEF16 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF16-associated genes across cancer lineages are MSH2, Stathmin, and Caspase-7-cleavedD198. Each is linked with ARHGEF16 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGEF16-to-partner and partner-to-ARHGEF16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by ARHGEF16-low versus ARHGEF16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF16→partner) and Y-score (partner→ARHGEF16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.263	-3.295	.002	.009	3	2
UCEC	Stathmin →	+0.123	+1.765	.016	.014	3	2
COAD	Caspase-7-cleavedD198 →	+1.449	+2.815	<.001	.036	1	4
UCEC	eIF4E →	+0.216	+2.713	.006	.003	3	1
UCEC	JNK2 →	+0.238	+1.594	.001	.042	3	1
UCEC	MEK1 →	+0.385	+2.662	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

MSH2 by ARHGEF16 expression — UCEC

Explore this box plot interactively →