ARHGEF16

Across TCGA cell cohorts, ARHGEF16 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,162 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ARHGEF16-associated GO terms across cancer lineages are Negative regulation of Arp2/3 complex-mediated actin nucleation, Establishment of epithelial cell apical/basal polarity, and ERBB3 signaling pathway. Each is linked with ARHGEF16 in more than 11 cancer types. Because this analysis shows association rather than direction, both ARHGEF16-to-partner and partner-to-ARHGEF16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of Arp2/3 complex-mediated actin nucleation grouped by ARHGEF16-low versus ARHGEF16-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF16→partner) and Y-score (partner→ARHGEF16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.169	+1.002	<.001	.006	3	12
URINARY_TRACT	Establishment of epithelial cell apical/basal polarity →	-0.250	-2.435	<.001	.001	3	12
LIVER	ERBB3 signaling pathway →	+0.276	+3.356	<.001	<.001	3	11
LIVER	ERBB2-ERBB3 signaling pathway →	+0.276	+3.356	<.001	<.001	3	11
OVARY	Cell-cell adhesion mediated by cadherin →	+0.256	+2.134	<.001	<.001	3	11
URINARY_TRACT	Megakaryocyte differentiation →	-0.199	-2.478	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,162 associations by consensus.

Negative regulation of Arp2/3 complex-mediated actin nucleation by ARHGEF16 expression — LARGE_INTESTINE

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