ARHGEF16

Across TCGA cell cohorts, ARHGEF16 mutation is significantly associated with the RNA expression of many other genes, with 234 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGEF16-associated genes across cancer lineages are OPRM1, TEX13A, and S100G. Each is linked with ARHGEF16 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF16-to-partner and partner-to-ARHGEF16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPRM1 grouped by ARHGEF16-low versus ARHGEF16-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF16→partner) and Y-score (partner→ARHGEF16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OPRM1 →	+0.138	+5.369	<.001	.004	3	2
OVARY	TEX13A →	+0.015	+3.405	<.001	.005	3	2
LARGE_INTESTINE	S100G →	+0.746	+2.425	.003	.004	3	2
LARGE_INTESTINE	NEXMIF →	+0.163	+2.459	<.001	.002	3	2
BLOOD_Myeloma	KRTAP19-3 →	+0.236	+4.807	<.001	.006	3	1
OVARY	FCRL4 →	+0.004	+3.405	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 234 associations by consensus.

OPRM1 by ARHGEF16 expression — SOFT_TISSUE

Explore this box plot interactively →