Across TCGA patient cohorts, ARHGEF15 protein abundance is significantly associated with the RNA expression of many other genes, with 6,407 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ARHGEF15-associated genes across cancer lineages are VWF, MMRN2, and CDH5. Each is linked with ARHGEF15 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGEF15-to-partner and partner-to-ARHGEF15 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF15→partner) and Y-score (partner→ARHGEF15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VWF →	+1.213	+0.712	.004	.008	3	4
BRCA	MMRN2 →	+0.913	+0.720	.003	.002	3	4
BRCA	CDH5 →	+1.067	+0.754	.006	.006	3	4
CCRCC	CLDN5 →	+1.107	+0.479	.001	<.001	3	4
LSCC	SHROOM4 →	+0.717	+0.226	<.001	<.001	3	4
UCEC	CILK1 →	-0.629	-0.416	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,407 associations by consensus.

Exploration

ARHGEF15 survival (RNA) · tumor vs normal (RNA) · all ARHGEF15 data types