Across TCGA patient cohorts, ARHGEF15 mutation is significantly associated with the RNA expression of many other genes, with 3,099 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF15-associated genes across cancer lineages are GOT1, DNAH3, and GLOD4. Each is linked with ARHGEF15 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGEF15-to-partner and partner-to-ARHGEF15 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF15→partner) and Y-score (partner→ARHGEF15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GOT1 →	+0.701	+3.348	<.001	.005	3	3
UCEC	DNAH3 →	-0.434	-2.113	.005	.003	3	3
UCEC	GLOD4 →	+0.363	+1.818	<.001	<.001	3	3
UCEC	TSR1 →	+0.364	+1.628	.001	<.001	3	3
UCEC	ELP5 →	+0.318	+1.839	<.001	<.001	3	3
UCEC	SLC22A4 →	-0.456	-1.629	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,099 associations by consensus.

Exploration

ARHGEF15 survival (RNA) · tumor vs normal (RNA) · all ARHGEF15 data types