Across TCGA patient cohorts, ARHGEF15 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF15-associated genes across cancer lineages are ASNS, eIF4E, and Cyclin-B1. Each is linked with ARHGEF15 in more than 4 cancer types. Because this analysis shows association rather than direction, both ARHGEF15-to-partner and partner-to-ARHGEF15 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF15→partner) and Y-score (partner→ARHGEF15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.696	+3.008	<.001	.019	3	5
UCEC	eIF4E →	+0.128	+1.584	.041	.002	3	4
UCEC	Cyclin-B1 →	+0.568	+2.999	<.001	<.001	3	4
LUSC	Ku80 →	+0.358	+3.027	.043	.018	3	3
COAD	TFRC →	+0.661	+3.025	.016	.019	3	3
COAD	4E-BP1 →	+0.306	+3.008	.007	.019	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Exploration

ARHGEF15 survival (RNA) · tumor vs normal (RNA) · all ARHGEF15 data types