Across TCGA cell cohorts, ARHGEF15 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGEF15-associated genes across cancer lineages are OR2D3, IL22, and HES3. Each is linked with ARHGEF15 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF15-to-partner and partner-to-ARHGEF15 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF15→partner) and Y-score (partner→ARHGEF15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR2D3 →	+0.015	+4.087	<.001	.009	3	1
SKIN	IL22 →	+0.020	+6.022	<.001	.001	3	1
SKIN	HES3 →	+0.083	+6.022	<.001	.001	3	1
SKIN	ENPP7 →	+0.013	+5.415	<.001	.004	3	1
LARGE_INTESTINE	FLT3 →	+0.178	+4.135	<.001	<.001	3	1
LARGE_INTESTINE	SEMG2 →	+0.524	+3.141	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Exploration

ARHGEF15 survival (RNA) · tumor vs normal (RNA) · all ARHGEF15 data types