Across TCGA patient cohorts, ARHGEF12 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,040 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ARHGEF12-associated proteins across cancer lineages are ARHGEF12_S309, PTPRC, and RNF214. Each is linked with ARHGEF12 in more than 6 cancer types. Because this analysis shows association rather than direction, both ARHGEF12-to-partner and partner-to-ARHGEF12 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF12→partner) and Y-score (partner→ARHGEF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGEF12_S309 →	+0.835	+0.737	<.001	<.001	3	7
GBM	PTPRC →	-0.812	-0.464	<.001	<.001	3	6
HNSC	RNF214 →	+0.209	+0.505	<.001	<.001	3	6
LSCC	BTK →	-0.486	-0.492	<.001	<.001	3	6
HNSC	CUL5 →	+0.256	+0.515	<.001	<.001	3	6
GBM	DOK3 →	-0.520	-0.303	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,040 associations by consensus.

Exploration

ARHGEF12 survival (RNA) · tumor vs normal (RNA) · all ARHGEF12 data types