Across TCGA patient cohorts, ARHGEF12 protein abundance is significantly associated with the RNA expression of many other genes, with 16,148 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ARHGEF12-associated genes across cancer lineages are KBTBD3, THEMIS2, and ARHGAP32. Each is linked with ARHGEF12 in more than 7 cancer types. Because this analysis shows association rather than direction, both ARHGEF12-to-partner and partner-to-ARHGEF12 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF12→partner) and Y-score (partner→ARHGEF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KBTBD3 →	+0.705	+0.428	<.001	<.001	3	8
GBM	THEMIS2 →	-1.014	-0.163	<.001	.001	3	7
BRCA	ARHGAP32 →	+1.070	+0.356	<.001	<.001	3	7
UCEC	KPNA2 →	-0.603	-0.203	<.001	<.001	3	7
OV	IFT46 →	+1.368	+0.628	.004	.004	3	6
OV	EI24 →	+0.987	+0.532	.006	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,148 associations by consensus.

Exploration

ARHGEF12 survival (RNA) · tumor vs normal (RNA) · all ARHGEF12 data types