Across TCGA patient cohorts, ARHGEF12 mutation is significantly associated with the RNA expression of many other genes, with 5,576 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF12-associated genes across cancer lineages are EXOSC9, IGHD4-17, and HMG20B. Each is linked with ARHGEF12 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGEF12-to-partner and partner-to-ARHGEF12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF12→partner) and Y-score (partner→ARHGEF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EXOSC9 →	+0.404	+2.243	<.001	<.001	3	4
UCEC	IGHD4-17 →	+0.454	+1.873	<.001	.001	3	4
UCEC	HMG20B →	+0.401	+3.413	<.001	<.001	3	4
UCEC	RDH11 →	+0.375	+3.021	<.001	<.001	3	4
STAD	RNA5SP248 →	+0.416	+3.416	.004	.007	3	3
SKCM	PPP2R2D →	+0.338	+2.616	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,576 associations by consensus.

Exploration

ARHGEF12 survival (RNA) · tumor vs normal (RNA) · all ARHGEF12 data types