Across TCGA patient cohorts, ARHGEF12 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF12-associated genes across cancer lineages are TFRC, p38-MAPK_pT180_Y182, and A-Raf_pS299. Each is linked with ARHGEF12 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGEF12-to-partner and partner-to-ARHGEF12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF12→partner) and Y-score (partner→ARHGEF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.463	+2.999	.001	<.001	3	4
SKCM	p38-MAPK_pT180_Y182 →	-0.443	-2.584	.005	.011	3	3
UCEC	A-Raf_pS299 →	-0.106	-1.584	.001	.008	3	2
UCEC	FoxM1 →	+0.149	+1.369	.036	.003	3	2
SKCM	JNK_pT183_Y185 →	-0.178	-3.000	.004	.035	3	2
UCEC	mTOR_pS2448 →	-0.106	-1.632	.010	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Exploration

ARHGEF12 survival (RNA) · tumor vs normal (RNA) · all ARHGEF12 data types