ARHGEF11

Across TCGA patient cohorts, ARHGEF11 protein abundance is significantly associated with the RNA expression of many other genes, with 10,578 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible ARHGEF11-associated genes across cancer lineages are SMOC2, FAM20B, and ETV3. Each is linked with ARHGEF11 in more than 4 cancer types. Because this analysis shows association rather than direction, both ARHGEF11-to-partner and partner-to-ARHGEF11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARHGEF11 versus SMOC2 in UCEC, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF11→partner) and Y-score (partner→ARHGEF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMOC2 →	+1.122	+0.170	<.001	<.001	3	5
LSCC	FAM20B →	+0.660	+0.129	<.001	<.001	3	5
UCEC	ETV3 →	+0.529	+0.169	<.001	<.001	3	5
UCEC	NENF →	+0.841	+0.183	.001	.001	3	5
HNSC	PIGC →	+0.781	+0.270	<.001	<.001	3	5
HNSC	MGST3 →	+0.557	+0.156	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,578 associations by consensus.

ARHGEF11 vs SMOC2 — UCEC

Explore this scatter interactively →