ARHGEF11

Across TCGA patient cohorts, ARHGEF11 protein abundance is significantly associated with the protein abundance of many other proteins, with 15,871 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ARHGEF11-associated proteins across cancer lineages are ARHGEF11_S1295, ARHGEF11_S1480, and CHD1L. Each is linked with ARHGEF11 in more than 7 cancer types. Because this analysis shows association rather than direction, both ARHGEF11-to-partner and partner-to-ARHGEF11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARHGEF11 versus ARHGEF11_S1295 in BRCA, with a Pearson correlation of 0.68.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF11→partner) and Y-score (partner→ARHGEF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGEF11_S1295 →	+0.449	+0.240	<.001	<.001	3	8
UCEC	ARHGEF11_S1480 →	+0.507	+0.197	<.001	.001	2	8
BRCA	CHD1L →	+0.312	+0.154	<.001	<.001	3	6
BRCA	PRUNE1 →	+0.347	+0.240	<.001	<.001	3	6
BRCA	ARHGEF11_S1478 →	+0.421	+0.201	<.001	<.001	3	5
BRCA	RPRD2 →	+0.349	+0.233	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,871 associations by consensus.

ARHGEF11 vs ARHGEF11_S1295 — BRCA

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