ARHGEF11

Across TCGA patient cohorts, ARHGEF11 mutation is significantly associated with the RNA expression of many other genes, with 3,580 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF11-associated genes across cancer lineages are EIF5A, SKA2, and CDKN3. Each is linked with ARHGEF11 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGEF11-to-partner and partner-to-ARHGEF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF5A grouped by ARHGEF11-low versus ARHGEF11-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF11→partner) and Y-score (partner→ARHGEF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	EIF5A →	+0.794	+3.186	<.001	.009	3	4
UCEC	SKA2 →	+0.375	+1.595	.004	<.001	3	4
UCEC	CDKN3 →	+0.426	+1.455	.005	.001	3	4
UCEC	PIMREG →	+0.553	+1.462	<.001	<.001	3	4
UCEC	SKA1 →	+0.503	+1.595	<.001	<.001	3	4
UCEC	FEN1 →	+0.409	+1.536	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,580 associations by consensus.

EIF5A by ARHGEF11 expression — STAD

Explore this box plot interactively →