ARHGEF11

Across TCGA patient cohorts, ARHGEF11 mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF11-associated genes across cancer lineages are GAPDH, ASNS, and PCNA. Each is linked with ARHGEF11 in more than 4 cancer types. Because this analysis shows association rather than direction, both ARHGEF11-to-partner and partner-to-ARHGEF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ARHGEF11-low versus ARHGEF11-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF11→partner) and Y-score (partner→ARHGEF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.625	+2.330	.006	.020	3	5
COAD	ASNS →	+0.647	+3.169	<.001	.018	3	5
STAD	PCNA →	+0.294	+2.321	.023	.034	3	4
STAD	Caspase-7-cleavedD198 →	+1.333	+3.321	<.001	.009	3	4
UCEC	Cyclin-E2 →	+0.113	+1.000	.016	.033	3	4
STAD	eIF4E →	+0.192	+2.321	.018	.034	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

GAPDH by ARHGEF11 expression — COAD

Explore this box plot interactively →