ARHGEF11

Across TCGA cell cohorts, ARHGEF11 mutation is significantly associated with the RNA expression of many other genes, with 1,594 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGEF11-associated genes across cancer lineages are OR10AG1, OR10G2, and LUZP4. Each is linked with ARHGEF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF11-to-partner and partner-to-ARHGEF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10AG1 grouped by ARHGEF11-low versus ARHGEF11-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF11→partner) and Y-score (partner→ARHGEF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR10AG1 →	+0.019	+5.000	<.001	.006	3	2
BLOOD_Leukemia	OR10G2 →	+0.600	+3.229	.001	<.001	3	2
LUNG_NSCLC_LUAD	LUZP4 →	+0.036	+3.215	<.001	.007	3	2
LUNG_NSCLC_LUAD	MTRNR2L10 →	+0.006	+4.266	<.001	.004	3	2
LARGE_INTESTINE	C12orf57 →	+0.798	+2.265	<.001	.001	3	2
LARGE_INTESTINE	HDDC2 →	+0.531	+3.321	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,594 associations by consensus.

OR10AG1 by ARHGEF11 expression — PANCREAS

Explore this box plot interactively →