ARHGEF10

Across TCGA patient cohorts, ARHGEF10 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,311 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible ARHGEF10-associated proteins across cancer lineages are ARHGEF10_S379, ARHGEF10_S59, and SEPTIN8. Each is linked with ARHGEF10 in more than 5 cancer types. Because this analysis shows association rather than direction, both ARHGEF10-to-partner and partner-to-ARHGEF10 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARHGEF10 versus ARHGEF10_S379 in OV, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF10→partner) and Y-score (partner→ARHGEF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ARHGEF10_S379 →	+0.877	+0.388	<.001	<.001	3	6
LSCC	ARHGEF10_S59 →	+0.730	+0.496	<.001	<.001	3	6
LSCC	SEPTIN8 →	+0.291	+0.320	<.001	.001	3	4
CCRCC	VCL_Y822 →	+0.390	+0.380	.003	.009	3	4
CCRCC	NID1 →	+0.521	+0.574	<.001	<.001	3	4
GBM	TLN1_Y70 →	+0.633	+0.369	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,311 associations by consensus.

ARHGEF10 vs ARHGEF10_S379 — OV

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