ARHGEF10

Across TCGA patient cohorts, ARHGEF10 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF10-associated genes across cancer lineages are FASN, Shc_pY317, and Caspase-7-cleavedD198. Each is linked with ARHGEF10 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGEF10-to-partner and partner-to-ARHGEF10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by ARHGEF10-low versus ARHGEF10-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF10→partner) and Y-score (partner→ARHGEF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FASN →	+0.465	+2.123	.002	.010	3	4
UCEC	Shc_pY317 →	-0.151	-1.777	<.001	.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.717	+1.604	<.001	.005	3	3
COAD	C-Raf →	+0.160	+2.123	.005	.010	3	3
COAD	GAPDH →	+0.463	+2.123	.020	.010	3	2
UCEC	NF2 →	+0.170	+1.662	.006	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

FASN by ARHGEF10 expression — COAD

Explore this box plot interactively →