ARHGEF10

Across TCGA cell cohorts, ARHGEF10 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,581 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ARHGEF10-associated GO terms across cancer lineages are Regulation of hippo signaling, Negative regulation of lysosome organization, and Protein depolymerization. Each is linked with ARHGEF10 in more than 13 cancer types. Because this analysis shows association rather than direction, both ARHGEF10-to-partner and partner-to-ARHGEF10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of hippo signaling grouped by ARHGEF10-low versus ARHGEF10-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF10→partner) and Y-score (partner→ARHGEF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of hippo signaling →	+0.104	+1.488	<.001	.001	3	14
LUNG_NSCLC_LUAD	Negative regulation of lysosome organization →	+0.108	+1.112	<.001	<.001	3	13
BREAST	Protein depolymerization →	+0.142	+1.605	<.001	<.001	3	13
URINARY_TRACT	Regulation of telomere capping →	+0.127	+1.748	<.001	.002	3	13
LUNG_NSCLC_LUSC	Actin filament depolymerization →	+0.201	+1.370	.001	.004	2	13
SOFT_TISSUE	Myelination in peripheral nervous system →	+0.139	+0.997	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,581 associations by consensus.

Regulation of hippo signaling by ARHGEF10 expression — BONE

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