ARHGEF1

Across TCGA patient cohorts, ARHGEF1 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,250 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible ARHGEF1-associated proteins across cancer lineages are SAMHD1, ANKRD44, and CLIC2. Each is linked with ARHGEF1 in more than 5 cancer types. Because this analysis shows association rather than direction, both ARHGEF1-to-partner and partner-to-ARHGEF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARHGEF1 versus SAMHD1 in HNSC, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF1→partner) and Y-score (partner→ARHGEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SAMHD1 →	+0.447	+0.448	<.001	<.001	3	6
OV	ANKRD44 →	+0.360	+0.661	.006	.005	3	6
OV	CLIC2 →	+0.466	+0.696	.001	.007	3	6
BRCA	CD8A →	+0.810	+0.675	<.001	<.001	3	6
BRCA	DOK2 →	+0.542	+0.767	<.001	<.001	3	6
UCEC	NFATC2 →	+0.494	+0.621	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,250 associations by consensus.

ARHGEF1 vs SAMHD1 — HNSC

Explore this scatter interactively →