ARHGEF1

Across TCGA patient cohorts, ARHGEF1 mutation is significantly associated with the RNA expression of many other genes, with 3,231 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF1-associated genes across cancer lineages are RNU7-128P, RNA5SP351, and PMPCA. Each is linked with ARHGEF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGEF1-to-partner and partner-to-ARHGEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-128P grouped by ARHGEF1-low versus ARHGEF1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF1→partner) and Y-score (partner→ARHGEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU7-128P →	+0.711	+3.580	<.001	.004	3	4
CESC	RNA5SP351 →	+0.360	+5.424	<.001	<.001	3	3
UCEC	PMPCA →	+0.279	+1.890	.004	<.001	3	3
UCEC	NCAPH2 →	+0.332	+1.857	.003	<.001	3	3
LUAD	LINC00556 →	+0.212	+4.218	.003	.009	3	3
UCEC	LMF2 →	+0.356	+4.243	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,231 associations by consensus.

RNU7-128P by ARHGEF1 expression — BRCA

Explore this box plot interactively →