ARHGEF1

Across TCGA patient cohorts, ARHGEF1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF1-associated genes across cancer lineages are Caspase-7-cleavedD198, ERK2, and GAPDH. Each is linked with ARHGEF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGEF1-to-partner and partner-to-ARHGEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ARHGEF1-low versus ARHGEF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF1→partner) and Y-score (partner→ARHGEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.644	+2.522	<.001	<.001	3	3
UCEC	ERK2 →	+0.184	+2.321	.002	<.001	3	2
UCEC	GAPDH →	+0.362	+1.440	.030	.022	3	2
UCEC	JNK2 →	+0.219	+2.834	<.001	.001	3	2
UCEC	MEK1 →	+0.223	+1.584	.049	.017	3	2
UCEC	p27_pT157 →	-0.047	-1.697	.008	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Caspase-7-cleavedD198 by ARHGEF1 expression — UCEC

Explore this box plot interactively →