ARHGEF1

Across TCGA cell cohorts, ARHGEF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,654 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARHGEF1-associated GO terms across cancer lineages are Regulation of calcium ion export across plasma membrane, Negative regulation of calcium ion export across plasma membrane, and Actomyosin contractile ring organization. Each is linked with ARHGEF1 in more than 14 cancer types. Because this analysis shows association rather than direction, both ARHGEF1-to-partner and partner-to-ARHGEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of calcium ion export across plasma membrane grouped by ARHGEF1-low versus ARHGEF1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF1→partner) and Y-score (partner→ARHGEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Regulation of calcium ion export across plasma membrane →	+0.124	+0.762	.006	.001	3	14
BREAST	Negative regulation of calcium ion export across plasma membrane →	+0.091	+0.533	<.001	.006	2	15
SKIN	Actomyosin contractile ring organization →	+0.177	+0.985	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Assembly of actomyosin apparatus involved in cytokinesis →	+0.173	+0.929	<.001	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Actomyosin contractile ring assembly →	+0.173	+0.929	<.001	.001	3	13
OVARY	Actomyosin contractile ring assembly actin filament organization →	+0.213	+1.018	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,654 associations by consensus.

Regulation of calcium ion export across plasma membrane by ARHGEF1 expression — BLOOD_Myeloma

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