ARHGEF1

Across TCGA cell cohorts, ARHGEF1 mutation is significantly associated with the RNA expression of many other genes, with 1,054 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARHGEF1-associated genes across cancer lineages are CHAT, DNAL4, and SLC32A1. Each is linked with ARHGEF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF1-to-partner and partner-to-ARHGEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHAT grouped by ARHGEF1-low versus ARHGEF1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF1→partner) and Y-score (partner→ARHGEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CHAT →	+0.531	+3.994	.009	<.001	3	2
BLOOD_Leukemia	DNAL4 →	+0.579	+3.259	.003	.006	3	2
BLOOD_Leukemia	SLC32A1 →	+0.669	+3.124	<.001	<.001	3	2
BLOOD_Leukemia	PCOLCE →	+1.656	+3.199	<.001	.007	3	2
BLOOD_Leukemia	APBA3 →	+0.558	+3.115	.002	.009	3	2
BLOOD_Leukemia	IL17F →	+0.038	+2.440	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,054 associations by consensus.

CHAT by ARHGEF1 expression — BLOOD_Leukemia

Explore this box plot interactively →