ARHGEF1

Across TCGA cell cohorts, ARHGEF1 mutation is significantly associated with the mutation status of many other genes, with 7,021 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGEF1-associated genes across cancer lineages are MROH7, FRAS1, and ABCA4. Each is linked with ARHGEF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ARHGEF1-to-partner and partner-to-ARHGEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MROH7 grouped by ARHGEF1-low versus ARHGEF1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF1→partner) and Y-score (partner→ARHGEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MROH7 →	+5.614	+5.044	.003	.003	1	5
CNS	FRAS1 →	+2.740	+4.237	.007	.007	1	5
SKIN	ABCA4 →	+3.392	+4.718	.002	.002	1	5
BLOOD_Lymphoma	TLR9 →	+4.108	+3.510	.003	.003	1	5
LARGE_INTESTINE	EPB41L3 →	+3.310	+4.182	<.001	<.001	1	5
SKIN	KIF1B →	+3.392	+4.718	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,021 associations by consensus.

MROH7 by ARHGEF1 expression — CNS

Explore this box plot interactively →