ARHGDIB

Across TCGA patient cohorts, ARHGDIB mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGDIB-associated genes across cancer lineages are eIF4E, ERK2, and FOXO3a_pS318_S321. Each is linked with ARHGDIB in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGDIB-to-partner and partner-to-ARHGDIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ARHGDIB-low versus ARHGDIB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGDIB→partner) and Y-score (partner→ARHGDIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.224	+3.169	.028	.019	3	1
UCEC	ERK2 →	+0.280	+3.169	.002	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.155	-3.459	.010	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.266	-3.321	.001	.010	3	1
UCEC	Ku80 →	+0.384	+3.598	<.001	.001	3	1
UCEC	Notch1 →	+0.245	+3.013	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eIF4E by ARHGDIB expression — UCEC

Explore this box plot interactively →