ARHGAP9

Across TCGA patient cohorts, ARHGAP9 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP9-associated genes across cancer lineages are ATM, MEK1, and PDCD4. Each is linked with ARHGAP9 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGAP9-to-partner and partner-to-ARHGAP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ARHGAP9-low versus ARHGAP9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP9→partner) and Y-score (partner→ARHGAP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.372	-1.523	.010	.008	3	3
UCEC	MEK1 →	+0.403	+2.058	<.001	<.001	3	2
UCEC	PDCD4 →	-0.549	-1.523	<.001	.008	3	2
SKCM	Rictor_pT1135 →	-0.176	-3.000	.017	.034	3	2
UCEC	TFRC →	+0.491	+2.584	.003	.001	3	2
UCEC	TIGAR →	+0.145	+1.765	.002	.013	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ATM by ARHGAP9 expression — UCEC

Explore this box plot interactively →