ARHGAP6

Across TCGA patient cohorts, ARHGAP6 mutation is significantly associated with the RNA expression of many other genes, with 4,968 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP6-associated genes across cancer lineages are TMX1, SNORD38C, and RNU7-143P. Each is linked with ARHGAP6 in more than 4 cancer types. Because this analysis shows association rather than direction, both ARHGAP6-to-partner and partner-to-ARHGAP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMX1 grouped by ARHGAP6-low versus ARHGAP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP6→partner) and Y-score (partner→ARHGAP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMX1 →	+0.428	+1.296	<.001	<.001	3	5
LIHC	SNORD38C →	+0.549	+5.033	<.001	.009	3	4
LGG	RNU7-143P →	+1.146	+5.206	<.001	.007	3	4
SKCM	GEMIN2 →	+0.386	+1.591	.006	.006	3	4
UCEC	PSMD6 →	+0.242	+1.593	.001	<.001	3	4
UCEC	CSRP2 →	+0.513	+1.595	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,968 associations by consensus.

TMX1 by ARHGAP6 expression — UCEC

Explore this box plot interactively →