ARHGAP6

Across TCGA patient cohorts, ARHGAP6 mutation is significantly associated with the total protein of many other genes, with 81 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP6-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and eEF2. Each is linked with ARHGAP6 in more than 4 cancer types. Because this analysis shows association rather than direction, both ARHGAP6-to-partner and partner-to-ARHGAP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ARHGAP6-low versus ARHGAP6-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP6→partner) and Y-score (partner→ARHGAP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caspase-7-cleavedD198 →	+1.125	+3.000	.003	.036	3	5
UCEC	Cyclin-B1 →	+0.488	+2.247	.001	.001	3	4
UCEC	eEF2 →	+0.306	+1.387	.001	.001	3	3
UCEC	EGFR_pY1068 →	-0.219	-1.544	<.001	<.001	3	3
UCEC	GAPDH →	+0.468	+1.807	<.001	.003	3	3
UCEC	JNK2 →	+0.258	+1.544	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

Caspase-7-cleavedD198 by ARHGAP6 expression — STAD

Explore this box plot interactively →