ARHGAP5

Across TCGA patient cohorts, ARHGAP5 mutation is significantly associated with the RNA expression of many other genes, with 5,989 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP5-associated genes across cancer lineages are CHORDC1, HSPA9, and RSRC1. Each is linked with ARHGAP5 in more than 4 cancer types. Because this analysis shows association rather than direction, both ARHGAP5-to-partner and partner-to-ARHGAP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHORDC1 grouped by ARHGAP5-low versus ARHGAP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP5→partner) and Y-score (partner→ARHGAP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHORDC1 →	+0.355	+1.871	.002	.001	3	5
UCEC	HSPA9 →	+0.525	+1.667	<.001	<.001	3	4
UCEC	RSRC1 →	+0.504	+1.514	<.001	<.001	3	4
SKCM	NUP35 →	+0.393	+3.182	.008	.009	3	4
UCEC	C1orf174 →	+0.398	+1.667	<.001	<.001	3	4
UCEC	PTMAP4 →	+0.768	+2.399	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,989 associations by consensus.

CHORDC1 by ARHGAP5 expression — UCEC

Explore this box plot interactively →