ARHGAP5

Across TCGA cell cohorts, ARHGAP5 mutation is significantly associated with the mutation status of many other genes, with 5,732 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGAP5-associated genes across cancer lineages are VCAN, RAPGEF4, and HSPG2. Each is linked with ARHGAP5 in more than 4 cancer types. Because this analysis shows association rather than direction, both ARHGAP5-to-partner and partner-to-ARHGAP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VCAN grouped by ARHGAP5-low versus ARHGAP5-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP5→partner) and Y-score (partner→ARHGAP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	VCAN →	+2.752	+2.847	.005	.005	1	5
LARGE_INTESTINE	RAPGEF4 →	+3.925	+2.824	<.001	<.001	1	5
LARGE_INTESTINE	HSPG2 →	+1.925	+2.643	<.001	<.001	1	5
LARGE_INTESTINE	RELN →	+1.478	+2.282	.001	.001	1	5
OVARY	MTMR3 →	+4.684	+3.562	.002	.002	1	4
BLOOD_Lymphoma	SYNE2 →	+1.975	+3.392	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,732 associations by consensus.

VCAN by ARHGAP5 expression — BLOOD_Lymphoma

Explore this box plot interactively →