ARHGAP45

Across TCGA pan-cancer cohorts, ARHGAP45 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ARHGAP45 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ARHGAP45 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARHGAP45 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

COAD, LUAD, and PDAC are the cancer types where ARHGAP45 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	II,III,IV	0.859	1.000	.033	42	view →
LUAD	DFS	Tertile	All	0.847	0.527	.003	10	view →
PDAC	OS	Median	III,IV	0.537	1.000	.008	8	view →
HNSC	DFS	Median	All	0.906	0.994	.004	7	view →
LSCC	DFS	Tertile	All	0.852	0.387	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ARHGAP45–COAD (DFS)

Open the COAD breakdown →