ARHGAP44

Across TCGA patient cohorts, ARHGAP44 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP44-associated genes across cancer lineages are NF2, Annexin-1, and ATM. Each is linked with ARHGAP44 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP44-to-partner and partner-to-ARHGAP44 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by ARHGAP44-low versus ARHGAP44-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP44→partner) and Y-score (partner→ARHGAP44) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF2 →	+0.177	+1.700	.014	.040	3	2
UCEC	Annexin-1 →	+0.415	+2.135	.018	.010	3	2
UCEC	ATM →	-0.385	-2.571	.011	.010	3	2
COAD	c-Kit →	-0.935	-3.169	.001	.018	3	2
UCEC	4E-BP1 →	+0.319	+1.874	<.001	.002	3	2
SKCM	AMPK_pT172 →	+0.293	+1.502	.014	.028	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

NF2 by ARHGAP44 expression — UCEC

Explore this box plot interactively →