ARHGAP42

Across TCGA patient cohorts, ARHGAP42 mutation is significantly associated with the RNA expression of many other genes, with 3,475 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP42-associated genes across cancer lineages are MRPL49, TIMM22, and C1QBP. Each is linked with ARHGAP42 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGAP42-to-partner and partner-to-ARHGAP42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL49 grouped by ARHGAP42-low versus ARHGAP42-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP42→partner) and Y-score (partner→ARHGAP42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL49 →	+0.434	+1.942	.001	.002	3	3
UCEC	TIMM22 →	+0.383	+2.432	<.001	<.001	3	3
COAD	C1QBP →	+0.865	+3.183	<.001	.009	3	3
UCEC	TOMM22 →	+0.312	+1.799	.007	.001	3	3
UCEC	KIF18A →	+0.583	+2.069	.001	<.001	3	3
CESC	LINC02840 →	+0.107	+2.746	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,475 associations by consensus.

MRPL49 by ARHGAP42 expression — UCEC

Explore this box plot interactively →