ARHGAP40

Across TCGA cell cohorts, ARHGAP40 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ARHGAP40-associated genes across cancer lineages are ADAM30, OR10C1, and BTN1A1. Each is linked with ARHGAP40 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP40-to-partner and partner-to-ARHGAP40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM30 grouped by ARHGAP40-low versus ARHGAP40-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP40→partner) and Y-score (partner→ARHGAP40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ADAM30 →	+0.006	+4.212	.008	.007	3	1
LUNG_NSCLC_LUAD	OR10C1 →	+0.050	+5.266	<.001	.001	3	1
SKIN	BTN1A1 →	+0.216	+4.095	<.001	.009	3	1
SKIN	OR1L3 →	+0.030	+6.000	<.001	<.001	3	1
SKIN	TRPC5 →	+0.013	+4.684	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ADAM30 by ARHGAP40 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →