ARHGAP4

Across TCGA patient cohorts, ARHGAP4 mutation is significantly associated with the RNA expression of many other genes, with 3,646 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP4-associated genes across cancer lineages are DDIT4, ZNF695, and ARHGAP11A. Each is linked with ARHGAP4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGAP4-to-partner and partner-to-ARHGAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DDIT4 grouped by ARHGAP4-low versus ARHGAP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP4→partner) and Y-score (partner→ARHGAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DDIT4 →	+0.906	+1.947	<.001	.002	3	4
CESC	ZNF695 →	+0.782	+3.199	.003	.009	3	3
UCEC	ARHGAP11A →	+0.736	+2.736	<.001	<.001	3	3
UCEC	SNRPD3 →	+0.382	+2.050	<.001	<.001	3	3
UCEC	CEP78 →	+0.575	+1.807	<.001	<.001	3	3
UCEC	FAM210A →	+0.523	+1.807	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,646 associations by consensus.

DDIT4 by ARHGAP4 expression — UCEC

Explore this box plot interactively →