ARHGAP4

Across TCGA patient cohorts, ARHGAP4 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP4-associated genes across cancer lineages are RAD51, ASNS, and Caspase-7-cleavedD198. Each is linked with ARHGAP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP4-to-partner and partner-to-ARHGAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by ARHGAP4-low versus ARHGAP4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP4→partner) and Y-score (partner→ARHGAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RAD51 →	+0.271	+3.178	<.001	.010	3	2
COAD	ASNS →	+0.805	+3.000	<.001	.034	3	2
COAD	Caspase-7-cleavedD198 →	+1.018	+2.824	.008	.034	3	2
UCEC	mTOR_pS2448 →	-0.152	-2.150	.003	.003	3	2
UCEC	N-Cadherin →	+0.192	+1.495	.009	.034	3	2
UCEC	PCNA →	+0.186	+2.070	.013	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

RAD51 by ARHGAP4 expression — COAD

Explore this box plot interactively →